JRP 02-05

Partners

CEA

FZD

Contact

Dr. C. Den Auwer
CEA Marcoule-DEN/DRCP/SCPS 30207 Bagnols-sur-Cèze - France
E-mail e-mail

Interaction of actinide cations with metalloproteins

Status

 
Terminated - Planned from February 2005 till August 2006

Goals

When metal ions are tightly bound to protein ligands, they are critical to the function, structure, and stability of proteins. Although the various interaction processes between the metallic cation and the protein are widely studied in all the fields of biochemistry, a focus on the specific actinide family is more seldom.

The present joint research project aims to describe the interactions of actinides with the protein Metal binding Domain in terms of:

  • the metallic coordination sphere;
  • further comparisons with endogenous transition metals.

Expected results

The results of this joint research project contribute to the understanding of the transport and interaction mechanisms of actinides with biological mechanism cycles. This will help to rationalize the molecular interactions and the associated hazards at cell level, which will lead to the development of efficient radioprotection and curative strategies.

Reports